Sirtmax® Kaempferia parviflora

Kaempferia parviflora is found in the upper Northeastern regions of Thailand. Root extracts have a long history of use and a reputation for being a health tonic and energy enhancer (i.e., Thai ginseng). The novel active constituents are a special type of polyphenol called polymethoxyflavonoids. Sirtmax^® Kaempferia parviflora root extract is standardized for polymethoxyflavonoid content.*

Top Benefits of Sirtmax®

Supports healthy aging*

Supports mitochondrial function*

Supports muscle strength and endurance*

Supports antioxidant defenses*

Neurohacker’s Sirtmax^® Sourcing

Sirtmax^® has been used in animal and human research studies.

Created by Tokiwa Phytochemicals, a leader in standardized Kaempferia parviflora supplementation. 

Highest concentration, full-spectrum root extract, with triple standardization for 5,7-dimethoxyflavone (≥ 4%), 3, 5, 7, 3', 4'-pentamethoxyflavone (≥ 3.5%), and total polymethoxyflavonoids (≥ 15%).

Grown in Thailand & Laos.

Sirtmax^® is a registered trademark of Tokiwa Phytochemical Co., Ltd.

Sirtmax^® Formulating Principles and Rationale

We consider Kaempferia parviflora to be in the adaptogenic herb category; following hormetic dosing principles (see Neurohacker Dosing Principles) with a high likelihood of having a hormetic range (i.e., a serving range below and above which results could be poorer). We have selected a serving that is within the studied range in humans.*

Kaempferia parviflora Key Mechanisms

Supports mitochondrial structure and function*

Supports transcription factors of mitochondrial biogenesis (PGC-1α, ERRα, NRF1, TFAM)* [1–3]

Supports mitochondrial number* [1]

Supports ATP production* [3]

Promotes β-oxidation (fatty acid metabolism) – upregulates PPARγ and PPARδ*  [2,4]

Promotes exercise performance*

Supports endurance performance* [1,2,5,6]

Supports post-exercise recovery* [1]

Supports muscle strength* [5,6]

Supports muscle metabolism* [1]

Supports healthy metabolic function*

Supports healthy fat accumulation and blood/liver lipid levels* [4,7,8]

Promotes differentiation of brown adipocyte cells* [4]

Supports UCP1 and thermogenesis of brown adipose tissue* [4,7,8]

Promotes whole-body energy expenditure through activation of brown adipose tissue* [7,9]

Promotes lean body mass* [2]

Promotes healthy aging and longevity* 

Supports neuroprotective functions* [10]

Counters the production of advanced glycation end-products (AGEs)* [11]

Promotes healthy cardiovascular NO signaling and vasodilation* [12–15]

Supports antioxidant enzymes* [5]

Supports AMPK signaling* [2,3]

Supports SIRT-1 signaling* [2,11]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

[1]K. Toda, S. Hitoe, S. Takeda, H. Shimoda, Heliyon 2 (2016) e00115.

[2]M.-B. Kim, T. Kim, C. Kim, J.-K. Hwang, J. Med. Food 21 (2018) 30–38.

[3]K. Toda, S. Takeda, S. Hitoe, S. Nakamura, H. Matsuda, H. Shimoda, J. Nat. Med. 70 (2016) 163–172.

[4]H. Kobayashi, E. Horiguchi-Babamoto, M. Suzuki, H. Makihara, H. Tomozawa, M. Tsubata, T. Shimada, K. Sugiyama, M. Aburada, J. Nat. Med. 70 (2016) 54–61.

[5]J. Wattanathorn, S. Muchimapura, T. Tong-Un, N. Saenghong, W. Thukhum-Mee, B. Sripanidkulchai, Evid. Based. Complement. Alternat. Med. 2012 (2012) 732816.

[6]K. Promthep, W. Eungpinichpong, B. Sripanidkulchai, U. Chatchawan, Med. Sci. Monit. Basic Res. 21 (2015) 100–108.

[7]T. Shimada, T. Horikawa, Y. Ikeya, H. Matsuo, K. Kinoshita, T. Taguchi, K. Ichinose, K. Takahashi, M. Aburada, Fitoterapia 82 (2011) 1272–1278.

[8]S. Yoshino, M. Kim, R. Awa, H. Kuwahara, Y. Kano, T. Kawada, Food Sci Nutr 2 (2014) 634–637.

[9]M. Matsushita, T. Yoneshiro, S. Aita, T. Kamiya, N. Kusaba, K. Yamaguchi, K. Takagaki, T. Kameya, H. Sugie, M. Saito, J. Nutr. Sci. Vitaminol. 61 (2015) 79–83.

[10]H.-I. Moon, S.-B. Cho, J.-H. Lee, Y.-C. Lee, J.-H. Lee, C.-H. Lee, S.-K. Kim, Phytother. Res. 25 (2011) 1215–1217.

[11]A. Nakata, Y. Koike, H. Matsui, T. Shimadad, M. Aburada, J. Yang, Nat. Prod. Commun. 9 (2014) 1291–1294.

[12]S.K. Wattanapitayakul, M. Suwatronnakorn, L. Chularojmontri, A. Herunsalee, S. Niumsakul, S. Charuchongkolwongse, N. Chansuvanich, J. Ethnopharmacol. 110 (2007) 559–562.

[13]P. Weerateerangkul, S. Palee, K. Chinda, S.C. Chattipakorn, N. Chattipakorn, J. Cardiovasc. Pharmacol. 60 (2012) 299–309.

[14]P. Tep-Areenan, P. Sawasdee, M. Randall, Phytother. Res. 24 (2010) 1520–1525.

[15]P. Tep-areenan, K. Ingkaninan, M.D. Randall, Asian Biomed. 4 (2010) 103–111.