Coleus forskohlii Root
Overview:
Forskolin is a labdane diterpene and the main bioactive compound in Coleus forskohlii, having nootropic and adaptogenic effects. Forskolin improves learning, memory and mental stamina.
Scientific Name:
Forskolin from Coleus Forskohlii
Mechanisms:
- Forskolin increases intracellular levels of cAMP through adenylate cyclase activation – increased responsiveness to extracellular stimuli[1]
- Improves stress response by improving cell communication in the HPA axis – adaptogenic effect[2]
- Synergistic with artichoke extract in increasing cAMP levels[1]
- Inhibits acetylcholinesterase – increased acetylcholine levels[3]
- Decreases fatigue[4]
- Anti-inflammatory effects[5]
REFERENCES
[1] Litosch I, Hudson TH, Mills I, Li SY, Fain JN (1982). Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes. Mol Pharmacol, 22(1):109-15. PMID: 6289066
[2] Kumari M, Cover PO, Poyser RH, Buckingham JC (1997). Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studies. Br J Pharmacol, 121(3):459-68. doi: 10.1038/sj.bjp.0701158
[3] Yang QR, Wu HZ, Wang XM, Zou GA, Liu YW (2006). Three new diterpenoids from Coleus forskohlii Briq. J Asian Nat Prod Res, 8(4):355-60. doi: 10.1080/10286020500172236
[4] Henderson S, et al (2005). Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr, 2:54-62. doi: 10.1186/1550-2783-2-2-54
[5] Menon DB, Latha K (2011). Phytochemical Screening and In vitro Anti-inflammatory Activity of the Stem of Coleus forskohlii. 3(23):75-79. doi: 10.5530/pj.2011.23.11