Eleuthero (Eleutherococcus senticosus) Root Extract

Eleuthero (Eleutherococcus senticosus; previously called Acanthopanax senticosus) is an adaptogenic herb most commonly used to support the body's natural ability to adapt to stress of everyday life. It is native to Eastern Russia (Siberia), Korea, Japan, and Northern China, and used in folk medicine in these regions. Prior to 2002, Eleuthero was commonly called “Siberian Ginseng,” but this changed in the U.S. with the passage of the Farm Bill, which restricted the use of the name ginseng in commerce exclusively to plants from the genus Panax (such as Panax ginseng). Despite once being known as Siberian Ginseng, and being from the same botanical family (Araliaceae) as ginseng,  Eleuthero should not be confused with true ginsengs, because each has some different active constituents (Eleuthero has eleutherosides, while ginsengs contain ginsenosides). Eleuthero was extensively studied in the former USSR as a means to support physical and mental stamina under normal conditions and during different types of physical and psychological stress [1]. Eleuthero was eventually recommended for use in the Soviet space program to promote adaptability to the stressful conditions of space. Eleutherococcus senticosus contains several bioactive compounds, the main being eleutherosides, which are found at the highest concentrations in the root of the plant.* 

TOP BENEFITS OF ELEUTHERO

Supports physical and mental stamina*

Supports healthy stress resistance*

NEUROHACKER’S ELEUTHERO SOURCING

Eleutherococcus senticosus Root Extract is standardized to contain not less than 1.2% Eleutheroside B+E. 

Eleutherococcus senticosus Root Extract is a non-GMO, gluten-free, and vegan ingredient.

ELEUTHERO FORMULATING PRINCIPLES AND RATIONALE

Eleuthero has been used in a range of servings depending on the type of extract, how concentrated it is, whether it was standardized, and if it has been used alone or combined with other ingredients. When used combined with other adaptogens, the serving of Eleuthero root extract used has ranged from 75 to 200 mg [2–6]. Since we are combining the Eleuthero extract with other adaptogens, we selected our recommended 100 mg serving to be within the studied range. We consider Eleuthero to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Neurohacker Dosing Principles). Herbal adaptogens tend to show a hormetic zone (or range) where there’s a favorable biological response. Clinical data suggests that it’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest serving that has been shown to produce the desired response. We opted for a recommended serving consistent with studied amounts as well as with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.*

ELEUTHERO KEY MECHANISMS

Supports healthy brain function*

Supports mental endurance* [1]

Supports cognitive function* [1,7]

Supports serotonin signaling* [8,9]

Supports dopamine signaling* [8,10]

Supports noradrenaline signaling* [8,10]

Supports BDNF levels* [11]

Supports neuroprotective functions* [12]

Supports healthy stress responses*

Supports healthy behavioral responses to stress* [11,13]

Supports healthy stress responses* [13]

Supports HPA axis function* [13]

Promotes exercise performance*

Supports endurance performance* [1,14]

Supports resistance to physical fatigue* [1,9,15,16]

Enhances antioxidant defenses*

Supports antioxidant defenses* [17]

Counters oxidative stress* [18,19]

Complementary ingredients*

Schisandra chinensis and Rhodiola rosea in supporting healthy stress responses* [20]

Extramel^®, taurine, and milk casein tryptic hydrolysate for stress support* [6]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

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[19]R. Wang, S. Liu, T. Liu, J. Wu, H. Zhang, Z. Sun, Z. Liu, Food Funct. 12 (2021) 4519–4534.

[20]A. Panossian, G. Wikman, P. Kaur, A. Asea, Phytomedicine 16 (2009) 617–622.