Celastrus Paniculatus Seed Extract


COMMON NAME

Celastrus | Intellect Tree | Jyotishmati


TOP BENEFITS OF CELASTRUS PANICULATUS

Supports cognitive performance*

Supports mood*

Supports stress response*


WHAT IS CELASTRUS PANICULATUS?

Celastrus paniculatus is native to India, where itโ€™s used by local healers primarily as a brain tonic for reasons that are consistent with one of its common names, โ€œthe intellect tree.โ€ Today weโ€™d recognize these uses as offering nootropic support. These uses include โ€œ...mental acuity, support memory and intellect as well as retention and recalling power; and to alleviate mental fatigue, stress...โ€*[1] It was believed that people using this plant would be able to learn new information more quickly, and more accurately and efficiently recall it later.*[1] Celastrus paniculatus seeds (and their oil) are what is used for cognitive support. The seeds contains a variety of active compounds, including sesquiterpenes such as celastrine, celapanine, celapanigine, celapagin, malkangunin and paniculatine. Celastrus paniculatus extracts have, in experimental research, positively influenced cognitive function and neuroprotective functions.*


NEUROHACKERโ€™S CELASTRUS PANICULATUS SOURCING

Celastrus paniculatus is an alcohol extract of the seeds.

Grown in India.

Celastrus paniculatus is non-GMO, gluten-free, and vegan. 


CELASTRUS PANICULATUS DOSING PRINCIPLES AND RATIONALE

One way Celastrus paniculatus was traditionally used was to have a person start by eating one seed a day in the diet, and then gradually increase by one seed a day, up to a maximum of 100 seeds daily.[1] This suggests to Neurohacker that the best way to approach dosing would be to consider Celastrus paniculatus as an adaptogenic herb; following hormetic dosing principles (see Neurohacker Dosing Principles) with a high likelihood of having a hormetic range (i.e., a dosing range below and above which results could be poorer). We have selected to dose this at a low-to-moderate amount because of both the traditional approach to use, and because of our N of 1 dosing experience in product development and testing.*


CELASTRUS PANICULATUS KEY MECHANISMS 

Supports brain function and cognition*

Supports memory and facilitates learning [2,5,7]

Counters experimentally-induced memory and learning impairments in animals [5,8โ€“11]

Supports the levels of monoamine neurotransmitters (noradrenaline, dopamine and serotonin) and their metabolites in the brain [2]

Interacts with dopamine-D2, serotonergic, GABAB, and NMDA receptors [3,4]

Influences brain MAO-A levels [3]

Influences acetylcholinesterase activity in the brain [5]

Supports brain content of total lipids and phospholipids [6]

Supports neuroprotective functions [4,11,13,14]


Supports a healthy mood and stress response*

Supports positive behavioral responses to stress [3,8,12]

Influences plasma corticosterone (stress hormone) levels [3]


Supports antioxidant defenses*

Supports antioxidant defenses [7,11,13โ€“17]

Counters oxidative stress [7,11,13โ€“17]

Supports free-radical-scavenging activity [14,16,18]


Other actions*

Supports healthy immune/cytokine signaling [17,19,20]

Supports relief of minor physical discomfort [19,20]

Supports gastroprotective functions [17]

Supports healthy cholesterol levels [21]


*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.


REFERENCES

[1]N. Arora, S.P. Rai, Int. J. Pharma Bio Sci. 3 (2012) 290โ€“303.
[2]K. Nalini, K.S. Karanth, A. Rao, A.R. Aroor, J. Ethnopharmacol. 47 (1995) 101โ€“108.
[3]R. Valecha, D. Dhingra, Basic Clin Neurosci 7 (2016) 49โ€“56.
[4]P.B. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, J. Ethnopharmacol. 93 (2004) 213โ€“219.
[5]M. Bhanumathy, M.S. Harish, H.N. Shivaprasad, G. Sushma, Pharm. Biol. 48 (2010) 324โ€“327.
[6]P.P. Bidwai, D. Wangoo, N.K. Bhullar, J. Ethnopharmacol. 21 (1987) 307โ€“314.
[7]M.H.V. Kumar, Y.K. Gupta, Phytomedicine 9 (2002) 302โ€“311.
[8]V. Bhagya, T. Christofer, B.S. Shankaranarayana Rao, Indian J. Pharmacol. 48 (2016) 687โ€“693.
[9]M. Gattu, K.L. Boss, A.V. Terry Jr, J.J. Buccafusco, Pharmacol. Biochem. Behav. 57 (1997) 793โ€“799.
[10]S.B. Raut, R.R. Parekar, K.S. Jadhav, P.A. Marathe, N.N. Rege, Anc. Sci. Life 34 (2015) 130โ€“133.
[11]J. Malik, M. Karan, R. Dogra, Pharm. Biol. 55 (2017) 980โ€“990.
[12]R. Rajkumar, E.P. Kumar, S. Sudha, B. Suresh, Fitoterapia 78 (2007) 120โ€“124.
[13]M. Chakrabarty, P. Bhat, S. Kumari, A. Dโ€™Souza, K.L. Bairy, A. Chaturvedi, A. Natarajan, M.K.G. Rao, S. Kamath, J. Pharmacol. Pharmacother. 3 (2012) 161โ€“171.
[14]P.B. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, Phytomedicine 13 (2006) 29โ€“36.
[15]G. Lekha, K. Mohan, I.A. Samy, Pharmacognosy Res. 2 (2010) 169โ€“174.
[16]P. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, Fitoterapia 74 (2003) 658โ€“669.
[17]S. Palle, A. Kanakalatha, C.N. Kavitha, J. Diet. Suppl. 15 (2018) 373โ€“385.
[18]A. Russo, A.A. Izzo, V. Cardile, F. Borrelli, A. Vanella, Phytomedicine 8 (2001) 125โ€“132.
[19]F. Ahmad, R.A. Khan, S. Rasheed, J. Ethnopharmacol. 42 (1994) 193โ€“198.
[20]Y.A. Kulkarni, S. Agarwal, M.S. Garud, J. Ayurveda Integr. Med. 6 (2015) 82โ€“88.
[21]R.H. Patil, K. Prakash, V.L. Maheshwari, Indian J. Clin. Biochem. 25 (2010) 405โ€“410.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.