In this article, we’re going to introduce an indirect way of supporting NAD⁺. Rather than making more, this article will be teaching you about using less. Using less requires downregulating a protein called cluster of differentiation 38 (CD38 for short). When CD38 is not as active, less NAD⁺ is used by it. The result is higher NAD⁺ levels and greater NAD⁺ availability for important healthy aging uses.

The NAD⁺ form of the molecule is required for certain cellular signaling reactions that change the way cells behave. Unlike redox, where the molecule is conserved, the NAD⁺ molecule is broken apart or “consumed” when used for signaling. It’s these NAD⁺ consumption uses that have been a main reason for the resurgence of scientific interest in strategies to boost NAD⁺.