Collective Insights Blog

Transcript: Valter Longo Interview on the Science of Longevity

Transcript: Valter Longo Interview on the Science of Longevity

There is so much advice on longevity and aging that it can be hard to sort through all of the information. In this podcast transcript we dive into the science-backed approaches for living a longer and healthier life. Valter Longo, Ph.D., has thirty years of experience in longevity and healthy eating, and is one of the world’s experts in the field.

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Mitochondria Functions For Healthy Aging: What does the Mitochondria do?

Mitochondria Functions For Healthy Aging: What does the Mitochondria do?

In this article, we will take a look at how mitochondrial dysfunction can cause damage to cells and mitochondrial quality control pathways act to prevent or overcome that damage. We will also discuss how aging affects mitochondrial function and nutritional strategies to support it.

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Eternus Survey Results

Eternus Survey Results

In September-October 2018, a 3-week sample of Eternus was sent to volunteers. Volunteers were selected to include a mix of people who were and were not currently taking Qualia. No information was given on what product was intended to do, ingredients contained in the product, or expected responses. Instructions were to take 8 capsules with breakfast 5 days a week, with 2 off days, for 3 weeks. All participants were asked to complete a survey questionnaire after 5 days, 2 weeks, and 3 weeks. Seventy-one persons completed the 3 weeks of supplementation and provided responses to the survey. 

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Mitohormesis: How Mitochondria Protect Themselves from Oxidative Stress

Mitohormesis: How Mitochondria Protect Themselves from Oxidative Stress

In this article, we’re going to learn about mitohormesis, the activity of reactive oxygen species (ROS) as signaling molecules, and how and why ROS can be both beneficial and harmful. We will also discuss what leads to excessive ROS production and accumulation, how this associates with aging, and where antioxidants fit into the equation. Lastly, we’ll discuss nutritional strategies that can support the antioxidant defenses cells and mitochondria use to protect themselves against excessive ROS.

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What is Mitochondrial Biogenesis? Benefits & Effects

What is Mitochondrial Biogenesis? Benefits & Effects

Similar to many other cellular processes, the creation of new mitochondria (a process called mitochondrial biogenesis), and the interacting pathways that influence it, suffers with aging. This is the bad news. The good news is that there are things we can do to better support maintaining a fitter mitochondrial network.

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What is CD38? An Exploration of NAD+ Consumption Uses and Functions of CD38

What is CD38? An Exploration of NAD+ Consumption Uses and Functions of CD38

In this article, we’re going to introduce an indirect way of supporting NAD+. Rather than making more, this article will be teaching you about using less. Using less requires downregulating a protein called cluster of differentiation 38 (CD38 for short). When CD38 is not as active, less NAD+ is used by it. The result is higher NAD+ levels and greater NAD+ availability for important healthy aging uses.

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Eternus: Putting the Healthy Aging Puzzle Together

Eternus: Putting the Healthy Aging Puzzle Together

We all age. But, we don’t all age at the same rate. From a bottom-up point of view, we are a complex colony of tens of trillions of individual cells. We care about what healthier cells allows the body to do better. Eternus is our solution to cell support for better aging. 

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Benefits of Gynostemma pentaphyllum Whole Herb Extract

Benefits of Gynostemma pentaphyllum Whole Herb Extract

Gynostemma pentaphyllum (Southern Ginseng) is an herb attributed with having ginseng status. Until fairly recently Gynostemma pentaphyllum was used primarily in mountainous regions of southern China and northern Vietnam. It’s been described as the "immortality herb,” because people within Guizhou Province, where herbal teas made from the plant are consumed regularly, are said to have a history of unusual longevity. 

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Benefits of Strawberry Seed Extract

Benefits of Strawberry Seed Extract

Strawberries are a good source of polyphenols. The seeds are an even better source. We made sure to source an extract standardized for at least 2% polyphenols. Studies of this extract suggest it might support healthy skin, weight, metabolism, and other functions needed for healthy aging.* Strawberry polyphenols would also be expected to support antioxidant defenses and overall cellular health.* But the main reason we included the strawberry seed extract is because it is a source of a specific flavonoid called tiliroside.

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Citrus sinensis L. Fruit Extract: Sources and Benefits

Citrus sinensis L. Fruit Extract: Sources and Benefits

Citrus × sinensis is the group of oranges that includes the commonly eaten navel orange and the blood orange. The peels and fruit are a rich source of citrus bioflavonoids. But our interest went beyond just including a generic citrus bioflavonoid mixture. What we were really interested in is a specific polymethoxylated flavone called nobiletin. Nobiletin has been identified as clock-enhancing small molecule, so is a key nutrient to support body clock functions.

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Sophorae japonica L. Flower Extract: Sources and Benefits

Sophorae japonica L. Flower Extract: Sources and Benefits

Rutin is a type of polyphenol called a flavonoid glycoside. It’s composed of quercetin and the disaccharide rutinose. It’s also called rutoside, quercetin-3-O-rutinoside and sophorin. While it’s found in a wide variety of plants, including citrus, foods with the highest concentrations of rutin include capers, black olives, buckwheat, and asparagus. The most common use of rutin has been for supporting healthy veins. But it does much more.

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Citrus grandis Fruit Extract: Sources And Benefits

Citrus grandis Fruit Extract: Sources And Benefits

Apigenin belongs to the flavone class of polyphenol compounds. It is one of the more common flavones in the diet, found in many fruits and vegetables, including celery and parsley. It’s also found in high amounts in the flowers used to make chamomile tea.

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Sirtmax® Kaempferia parviflora Root Extract: Sources And Benefits

Sirtmax® Kaempferia parviflora Root Extract: Sources And Benefits

Kaempferia parviflora is found in the upper northeastern regions of Thailand. It is commonly called black ginger, because of the intense purple-black color and similar shape of the roots to ginger. The traditional use has been as a health tonic and energy enhancer leading to it sometimes being called “Thai ginseng.” The novel active constituents are polymethoxyflavonoids polyphenols. 

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Polyphenols: Sources and Benefits

Polyphenols: Sources and Benefits

Dietary polyphenols are a family of plant compounds found in common foods including fruits, vegetables, nuts, chocolate, coffee, and tea. These compounds play important roles in the plant kingdom, protecting plants from infections, pests, UV irradiation from the sun, oxidative stress, and toxic metals and chemicals.

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Anti-Aging Benefits of Intermittent Fasting

Anti-Aging Benefits of Intermittent Fasting

In Silicon Valley, the hub of anti-aging research and funding, countless entrepreneurs and high-profile celebrities use fasting to combat the effects of aging. In Anti-Aging Benefits of Fasting, we will explore the mechanisms that create these fasting benefits. This part is more scientific than the others, but we emphasize only crucial components in an easily digestible format.

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What to Expect While Intermittent Fasting

What to Expect While Intermittent Fasting

In What to Expect While Fasting we explore how some biohackers are using traditional caloric restriction, some of the purported benefits, and what you can expect. This provides more in-depth context for fasting and how you might be able to apply it in your life.

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12 Ways To Upgrade Your Lifespan & Healthspan IQ

12 Ways To Upgrade Your Lifespan & Healthspan IQ

The amount of time we live is called lifespan. The length of time that a person is healthy and functional—not just alive—is called healthspan. Scientific understanding in these areas is advancing rapidly. Below are 12 things the collective thinks will help on your journey to a longer healthier you. 

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