Collective Insights Blog

 How is NAD+ Made? Preiss-Handler Pathway

How is NAD+ Made? Preiss-Handler Pathway

In 1958, Jack Preiss and Philip Handler published a scientific paper describing how NAD+ was made from niacin in three steps.(1) This pathway was later named the Preiss-Handler pathway after the co-discoverers. It describes the enzyme steps needed to convert niacin into the NAD+ molecule.

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How is NAD+ Made? Salvage Pathway

How is NAD+ Made? Salvage Pathway

The salvage pathway is used to produce NAD+ from nicotinamide molecules. Whether the source of the nicotinamide is vitamin B3 (as niacinamide), newer nicotinamides (e.g., nicotinamide riboside [NR], nicotinamide mononucleotide [NMN]), or molecules in food that get broken down during digestion into nicotinamide, the salvage pathway turns them into NAD+ in our tissues.

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How is NAD+ Made? De Novo Synthesis

How is NAD+ Made? De Novo Synthesis

Key Learning Objectives

  • Start to appreciate why redundancy is important in living systems.
  • Introduce the three pathways used to make NAD+.
  • Discover how L-tryptophan at breakfast influences what happens at night.
  • Learn about how L-tryptophan is used to make NAD+. 
  • Find out which dietary nutrients support making NAD+ from L-tryptophan
  • Understand why preventing a build-up of quinolinic acid (QA) is important.

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