Centrophenoxine

Overview:
Centrophenoxine is a cholinergic compound with long-term neuroprotective and nootropic activity. Studies indicate that centrophenoxine can improve working memory and be a general memory enhancer.

Scientific Name:
2-Dimethylaminoethyl(4-chlorophenoxy)acetate

Mechanisms:

  • Increases the levels of Acetylcholine in the brain[1]
  • Anti-aging effects[2]
  • Decreases the accumulation of cellular waste and toxins in the brain[3]
  • Antioxidant effect – decreases lipid peroxidation
  • Increases RNA and protein synthesis in the brain[4]
  • Increases glucose uptake in neurons and glia[5]
  • Decreases cognitive decline by reducing cellular dehydration[6]
  • Increases synaptic connections – improved neuronal communication[7]
References

[1] Wood PL & Péloquin A (1982). Increases in choline levels in rat brain elicited by meclofenoxate. Neuropharmacology, 21(4):349-54. doi: 10.1016/0028-3908(82)90099-5
[2] Bhalla P & Nehru B (2005). Modulatory effects of centrophenoxine on different regions of ageing rat brain. Exp Gerontol, 40(10):801-6. doi: 10.1016/j.exger.2005.06.016
[3] Nehru B1 & Bhalla P (2006). Reversal of an aluminium induced alteration in redox status in different regions of rat brain by administration of centrophenoxine. Mol Cell Biochem, 290(1-2):185-91. doi: 10.1007/s11010-006-9186-7
[4] Sharma D, et al (1993). Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine. Neurobiol Aging, 14(4):319-30. doi: 10.1016/0197-4580(93)90117-T
[5] Watanabe S, et al (1975). Effects of various cerebral metabolic activators on glucose metabolism of brain. Folia Psychiatr Neurol Jpn, 29(1):67-76. doi: 10.1111/j.1440-1819.1975.tb02324.x
[6] Zs-Nagy I (1989). On the role of intracellular physicochemistry in quantitative gene expression during aging and the effect of centrophenoxine. A review. Arch Gerontol Geriatr, 9(3):215-29. doi: 10.1016/0167-4943(89)90042-3
[7] Bertoni-Freddari C, et al (1982). The effect of acute and chronic centrophenoxine treatment on the synaptic plasticity of old rats. Arch Gerontol Geriatr, 1(4):365-73. doi: 10.1016/0167-4943(82)90036-X